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WebTrandolapril is a prodrug that is de-esterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin–angiotensin–aldosterone system. Trandolapril has a half-life of about 6 hours, and trandolaprilat has a half life of about 10 h. Trandolaprilat has about eight times the activity of its parent drug. WebDec 7, 2015 · Hypertension affects almost 43 million adults (≥18 years old) in the United States. 1 Fifty-two percent of them receive pharmacologic treatment, but only 24% have their blood pressure (BP) controlled (systolic BP <140 and diastolic BP <90mm Hg). 1 Medication non-adherence (taking <80% of the number of prescribed pills) 2 occurs in about 50% of … WebConclusion: The benefit of antihypertensive back titration apart from psychological relief of lower pill burden and side effect profile is in pharmacoeconomics. This permits greater adherence and prevents morbi-mortality consequences of hypertension. In this study, back titration over 12 months translated to average cost reduction of >50% ... citroen ds3 black and pink