WebImpairment of PINK1/Parkin-mediated mitophagy has provided a potential explanation for the mitochondrial dysfunction observed in cellular and animal models of PINK1 or Parkin deficiency ( Gegg et al., 2010; Park et al., 2006; Schapira and Gegg, 2011; Ziviani et al., 2010) and cardiomyocytes lacking Mfn2 ( Chen and Dorn, 2013). WebJul 5, 2024 · The core mechanism of PINK1/Parkin-mediated mitophagy is the generation of ubiquitin chains recognized by autophagic receptors. However, mitochondrial receptors such as BNIP3 and FUNDC1 contain a conserved LIR motif and directly bind to LC3 on autophagosomes by the LIR motif.
The PINK1-Parkin mitophagy signalling pathway is not functional …
WebDuring mitophagy, PINK1 (PTEN induced kinase 1), a serine/threonine kinase, works with PRKN/parkin, an E3 ubiquitin ligase, to target damaged mitochondria to the lysosome for … WebNov 11, 2024 · An early step in PINK1 -Parkin mediated mitophagy is the ubiquitination of the mitofusin proteins MFN1 and -2. The ubiquitination of MFN1 and -2 in patient samples … indian river mall theater
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy …
WebApr 7, 2024 · PINK1/Parkin-mediated mitophagy is traditionally considered in the context of mitochondrial depolarization by promoting the turnover of isolated damaged mitochondria, but ULK1-mediated Parkin phosphorylation downstream of AMPK directly connects Parkin to the highly conserved AMPK energy sensing response, which is activated by a wide … WebJan 3, 2024 · Resveratrol attenuated Cd-induced excessive mitochondrial fission and promoted mitochondrial fusion, which reversed PINK1/Parkin-mediated mitophagy initiation. Collectively, our findings explicate the potential protection against Cd-induced nephrotoxicity and mitochondria damage. WebMitophagy is a cargo-specific autophagic process that recycles damaged mitochondria to promote mitochondrial turnover. PTEN-induced putative kinase 1 (PINK1) mediates the … loch katrine walkhighlands