Phosphopantetheine binding
http://amigo.geneontology.org/amigo/term/GO:0031177 WebMar 8, 2024 · cl09936: PP-binding Superfamily. Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group …
Phosphopantetheine binding
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WebJan 4, 2024 · Crystal structures of the PCP-reductase didomain reveal that phosphopantetheine binding alters the orientation of a key Asp, resulting in a productive orientation of the bound nicotinamide. This ensures that further reduction of the aldehyde product does not occur. Combining crystallography with small-angle X-ray scattering … Webcytoskeleton and flagella extracellular region protein binding, modification* transmembrane transport cellulose binding calcium ion binding microtubule-based movement calcium channel complex NAD(P)H oxidase activity small GTPase signal cell regulation and signalling* proteolysis* positive regulation of GTPase activity membrane kinesin complex
WebNDA 021160/S-015 Page 2 with PhosLo. Progressive hypercalcemia due to overdose of PhosLo may be severe as to require emergency measures. Chronic hypercalcemia may … WebSep 5, 2008 · The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide synthases.
WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas pyrophosphate was competitive with ATP ... WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production.
WebSep 4, 2024 · phosphopantetheine binding pocket, away from the solvent channel, forming a hydrogen bond with . Val73, and interacting via water molecules (not shown) with Gly71, Val74 and Asn105 (Figure 2C).
WebStructural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Phosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) … grace of mary greek cypriot hostelWebMercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors By Maurício T. Tavares chillinit net worthPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. chillin it lyrics youtubeWebAug 31, 2015 · CoA and 4′-phosphopantetheine levels were also significantly reduced in all conditions (Supplementary Fig. 12b–e), with the exception of dCOASY mutants, which showed a significant reduction of ... chillinit women weed \u0026 wordplayWebOct 5, 2007 · Together with docking simulations that identified a potential phosphopantetheine binding groove, the structural and functional studies reveal that the C9 specificity is a result of active site geometry and substrate ring constraints. The results lay the foundation for the design of novel aromatic polyketide natural products with different ... grace of mary eppingWebApr 15, 1999 · The hydrogen bond between the amide of Met74 and the carboxylic oxygen at the elbow of the pantetheine arm stabilizes the bent configuration. In the free protomer, residues 72–74 hinder binding of 4′-phosphopantetheine and would result in steric conflict between Met74 and carboxylic oxygen, thus entailing backbone movement prior to binding. grace of norrath buff eq2WebJul 17, 2024 · A phosphopantetheine-binding-induced activation mechanism To verify our hypothesis, we determined the crystal structure of the CAR sr PCP–reductase (PCP–R) … chillinit one breath one take lyrics