Cisplatin liver toxicity

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August undefined, 2024

WebAbstract. Cisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … WebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment. Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.

Cisplatin - Drug Information - Chemocare

WebPaclitaxel, Ifosfamide and Cisplatin Regimen is Feasible for —文档、资料、论文、办公、总结，均是精品资料，免费阅读，免费分享，值得下载！ WebConclusions: We observed that there is an important relationship between CYP450 and cisplatin, involving increased toxicity. However, the possible mechanisms described for the involvement of CYP450 enzymes in nephrotoxicity and hepatotoxicity induced by cisplatin need to be confirmed by further studies. images of pinfish

The role of natural antioxidants in cisplatin-induced hepatotoxicity

WebApr 12, 2024 · Currently, gemcitabine/cisplatin is first-line therapy for advanced iCCA based on the ABC-02 clinical trial (ClinicalTrials.gov identifier NCT02170090). That phase 3 study included 410 patients with locally advanced or metastatic CCA, gallbladder cancer, or ampullary cancer. WebNov 7, 2024 · Hence, higher mitochondrial content directly correlates with sensitivity to cisplatin induced apoptosis. As mitochondrial reactive oxygen species are known to be toxic, we next analyzed the... WebThe RRs were 22% and 22%, respectively. One-year survival rates were 31% and 36%, respectively. What we have researched was Abraxane plus cisplatin and gemcitabine plus cisplatin, and their RRs were higher than ECOG 1594 clinical trials. The RR between the TP group and GP group also had significant difference. images of pinewood derby cars

Multidisciplinary management in the treatment of intrahepatic ...

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WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was to evaluate the incidence of chemotherapy toxicity induced by cisplatin and to analyze the influence of risk factors in the Tunisian population. WebSome articles have reported severe toxicities induced by cisplatin/5-fluorouracil regimens, nevertheless, severe and lethal liver toxicity has not been previously reported. In this article, we report the case of a 72-year-old woman, who developed fulminant hepatitis, hypoglycemia and hypotension with atrial fibrillation not responding to treatment. list of banned eye dropsWebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … list of banned dogs in uk

"WebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast … " - Cisplatin liver toxicity

Cisplatin liver toxicity

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing …

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). WebCisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. The current study presents a pharmacological review on the drug including its mechanism of action, resistance mechanism, and toxicity as well as its clinical applications.

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WebOct 26, 2005 · It is possible that cisplatin-induced oxidative stress and CYP2E1-mediated oxidative stress synergize to produce hepatotoxicity. In the present study, the effect of increased CYP2E1 expression on cisplatin-induced hepatotoxicity was investigated. WebSep 15, 2024 · Liver injury from cisplatin is rare and when it does occur, the severity in published cases was generally mild and the outcome benign. There is likely to be cross sensitivity to liver toxicities of the various platinum coordination complexes and …

WebCis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter for cis-platin nephrotoxicity in isolated human proximal tubules and offer a potential mechanism for reducing nephrotoxicity in clinical practice. WebWorld Health Organization

WebGEMCITABINE-CISPLATIN is used to treat: Biliary tract cancer. Bladder cancer. Cervical cancer. Malignant mesothelioma. Non-small cell lung cancer (NSCLC). Ovarian cancer. … WebOct 5, 2014 · Oxidative stress is the one of most important mechanisms involved in cisplatin toxicity. The mitochondrion is the primary target for cisplatin induced oxidative stress, ... Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chem.Biol.Interact. 2007; 170:177–186. [Google Scholar]

WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …

WebFeb 2, 2024 · The liver is an important central organ for metabolism and detoxification in the human body and is susceptible to many factors, such as excessive alcohol consumption, hepatoviruses, various toxins, and drugs, leading to the development of liver diseases. ... Toxicity of Cisplatin to the central Nervous System of Male Rabbits. Bter 74 (3), 223 ... list of banned films in australiaWebFeb 16, 2024 · NEPHROTOXICITY: This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure … images of pine tree needlesWebJun 13, 2024 · Cisplatin toxicity Toxicity signs are characterized by nausea and vomiting, nephrotoxicity, neurotoxicity, ototoxicity, and hepatotoxicity [ 26 ], observed after administration of high doses of cisplatin [ 27, 28 ], or after repeated low doses. list of banned episodesWebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. images of pine tree drawingsWebIts stereoisomer transplatin does not have any toxicity at equimolar concentrations, and it also possesses little antitumor activity. In this study, subcellular localization of both the platinum isomers was examined in the liver and kidney of the mouse 24 hours following the drug administration. list of banned guns c21WebApr 4, 2024 · Carboplatin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve ). Tell your doctor about all your current medicines. list of banned dog breeds in dubaiWebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver … list of banned episodes wiki